Open Access and the REF: Issues and Potential Solutions Workshop: Executive Summary

This report provides a summary of the discussion and findings of the Open Access and the REF: Issues and Potential Solutions workshop held as part of the End-to-End Project. The workshop was highly interactive and feedback received indicated it was considered an excellent event, and that it was vital and useful to bring together various key stakeholders to discuss problems and procedures and develop ideas

Contested framings of greenhouse gas removal and its feasibility: social and political dimensions

Prospective approaches for large‐scale greenhouse gas removal (GGR) are now central to the post‐2020 international commitment to pursue efforts to limit the global temperature increase to 1.5°C. However, the feasibility of large‐scale GGR has been repeatedly questioned. Most systematic analyses focus only on the physical, technical, and economic challenges of deploying it at scale. However, social and political dimensions will be just as important, if not more so, to how possible futures play out. We conduct one of the first reviews of the international peer‐reviewed literature pertaining to the social and political dimensions of large‐scale GGR, with a specific focus on two predominant approaches: Biomass energy with carbon capture and storage (BECCS) and afforestation/reforestation (AR). Our analysis of 78 studies proposes two important insights. First, it shows how six key social and political dimensions of GGR feasibility–namely economics and incentives; innovation; societal engagement; governance; complexity and uncertainty; and ethics, equity, and justice–are identifiable and are emphasized to varying degrees in the literature. Second, there are three contested ways in which BECCS and AR and their feasibility are being framed in the literature: (a) a techno‐economic framing; (b) a social and political acceptability framing; and (c) a responsible development framing. We suggest this third frame will, and indeed should, become increasingly pertinent to the assessment, innovation, and governance of climate futures

Research report for supporting practice research works (P1623, 2.2)

Documents best practice in supporting practice research works at other HE institutions including; policy, definitions, vocabulary options, metadata, workflows, repository advice and features, digitisation offers, case studies and advocacy. Report collated through visits to Goldsmiths and University of Creative Arts, conference calls to University of Westminster and Glasgow School of Arts and desk research of other UK and Australian HE Institutions

Interaction of the hydrogen sulfide system with the oxytocin system in the injured mouse heart

Both the hydrogen sulfide/cystathionine-γ-lyase (H2S/CSE) and oxytocin/oxytocin receptor (OT/OTR) systems have been reported to be cardioprotective. H2S can stimulate OT release, thereby affecting blood volume and pressure regulation. Systemic hyper-inflammation after blunt chest trauma is enhanced in cigarette smoke (CS)-exposed CSE−/− mice compared to wildtype (WT). CS increases myometrial OTR expression, but to this point, no data are available on the effects CS exposure on the cardiac OT/OTR system. Since a contusion of the thorax (Txt) can cause myocardial injury, the aim of this post hoc study was to investigate the effects of CSE−/− and exogenous administration of GYY4137 (a slow release H2S releasing compound) on OTR expression in the heart, after acute on chronic disease, of CS exposed mice undergoing Txt.Methods: This study is a post hoc analysis of material obtained in wild type (WT) homozygous CSE−/− mice after 2-3 weeks of CS exposure and subsequent anesthesia, blast wave-induced TxT, and surgical instrumentation for mechanical ventilation (MV) and hemodynamic monitoring. CSE−/− animals received a 50 μg/g GYY4137-bolus after TxT. After 4h of MV, animals were exsanguinated and organs were harvested. The heart was cut transversally, formalin-fixed, and paraffin- embedded. Immunohistochemistry for OTR, arginine-vasopressin-receptor (AVPR), and vascular endothelial growth factor (VEGF) was performed with naïve animals as native controls.Results: CSE−/− was associated with hypertension and lower blood glucose levels, partially and significantly restored by GYY4137 treatment, respectively. Myocardial OTR expression was reduced upon injury, and this was aggravated in CSE−/−. Exogenous H2S administration restored myocardial protein expression to WT levels.Conclusions: This study suggests that cardiac CSE regulates cardiac OTR expression, and this effect might play a role in the regulation of cardiovascular function

Tumour necrosis factor-alpha expression in tumour islets confers a survival advantage in non-small cell lung cancer

<p>Abstract</p> <p>Background</p> <p>The role of TNFα in cancer is complex with both pro-tumourigenic and anti-tumourigenic roles proposed. We hypothesised that anatomical microlocalisation is critical for its function.</p> <p>Methods</p> <p>This study used immunohistochemistry to investigate the expression of TNFα in the tumour islets and stroma with respect to survival in 133 patients with surgically resected NSCLC.</p> <p>Results</p> <p>TNFα expression was increased in the tumour islets of patients with above median survival (AMS) compared to those with below median survival (BMS)(p = 0.006), but similar in the stroma of both groups. Increasing tumour islet TNFα density was a favorable independent prognostic indicator (p = 0.048) while stromal TNFα density was an independent predictor of reduced survival (p = 0.007). Patients with high TNFα expression (upper tertile) had a significantly higher 5-year survival compared to patients in the lower tertile (43% versus 22%, p = 0.01). In patients with AMS, 100% of TNFα⁺cells were macrophages and mast cells, compared to only 28% in the islets and 50% in the stroma of BMS patients (p < 0.001).</p> <p>Conclusions</p> <p>The expression of TNFα in the tumour islets of patients with NSCLC is associated with improved survival suggesting a role in the host anti-tumour immunological response. The expression of TNFα by macrophages and mast cells is critical for this relationship.</p

Comparative performances of machine learning methods for classifying Crohn Disease patients using genome-wide genotyping data

Abstract: Crohn Disease (CD) is a complex genetic disorder for which more than 140 genes have been identified using genome wide association studies (GWAS). However, the genetic architecture of the trait remains largely unknown. The recent development of machine learning (ML) approaches incited us to apply them to classify healthy and diseased people according to their genomic information. The Immunochip dataset containing 18,227 CD patients and 34,050 healthy controls enrolled and genotyped by the international Inflammatory Bowel Disease genetic consortium (IIBDGC) has been re-analyzed using a set of ML methods: penalized logistic regression (LR), gradient boosted trees (GBT) and artificial neural networks (NN). The main score used to compare the methods was the Area Under the ROC Curve (AUC) statistics. The impact of quality control (QC), imputing and coding methods on LR results showed that QC methods and imputation of missing genotypes may artificially increase the scores. At the opposite, neither the patient/control ratio nor marker preselection or coding strategies significantly affected the results. LR methods, including Lasso, Ridge and ElasticNet provided similar results with a maximum AUC of 0.80. GBT methods like XGBoost, LightGBM and CatBoost, together with dense NN with one or more hidden layers, provided similar AUC values, suggesting limited epistatic effects in the genetic architecture of the trait. ML methods detected near all the genetic variants previously identified by GWAS among the best predictors plus additional predictors with lower effects. The robustness and complementarity of the different methods are also studied. Compared to LR, non-linear models such as GBT or NN may provide robust complementary approaches to identify and classify genetic markers

Genomic Dissection of Bipolar Disorder and Schizophrenia, Including 28 Subphenotypes

publisher: Elsevier articletitle: Genomic Dissection of Bipolar Disorder and Schizophrenia, Including 28 Subphenotypes journaltitle: Cell articlelink: https://doi.org/10.1016/j.cell.2018.05.046 content_type: article copyright: © 2018 Elsevier Inc

University of Kent RCUK Open Access compliance report 2017-18

This spreadsheet records open access article processing charges (APCs)paid from University of Kent's Research Councils UK (RCUK) open access budget between 1 April 2017 and 31 March 2018, along with University of Kent’s overall compliance with the RCUK open access policy. RCUK was subsumed by UK Research and Innovation (UKRI) on 1 May 2018. The report was presented to UK Research and Innovation (UKRI) on 23 May 201

University of Kent UKRI Open Access compliance report 2018-2019

This spreadsheet records open access article processing charges (APCs) paid from University of Kent's UK Research and Innovation (UKRI) open access budget between 1 April 2018 and 31 March 2019, along with University of Kent’s overall compliance with the UKRI open access policy. UK Research and Innovation (UKRI) subsumed Research Council UK (RCUK) on 1 May 2018. The report was presented to UK Research and Innovation (UKRI) on {ADD DATE